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Successful Treatment With an Anti-CD20 Monoclonal Antibody

Laurent Parmentier, MD, PhD; Blaise-Alain Bron, MD; Christa Prins, MD; Jacky Samson, MD; Isabelle Masouyé, MD; Luca Borradori, MD

Arch Dermatol. 2008;144(11):1427-1430.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

REPORT OF A CASE

A 53-year-old woman presented with generalized mucocutaneous lichen planus (LP) with progressive oral and retrosternal burning, accompanied by progressive dysphagia. She had a 9- and 5-year history of buccal and vulvar LP, respectively, both of which were partially controlled by short-term courses of corticosteroids, administered either topically or systemically. Skin examination revealed numerous papules of active LP and postinflammatory hyperpigmented macules on the flexural areas of the arms, axillae, and submammary and inguinal folds, as well as on the umbilical and lumbosacral areas. In the genital area, atrophic changes were evident on the labia minorum. White, reticulated, erosive lesions were observed on the jugal and gingival mucosae, and patchy whitish lesions were seen on the tongue and palate. Esophagoscopy demonstrated lesions consistent with LP spreading downward to the superior sphincter, with . . . [Full Text of this Article]

THERAPEUTIC CHALLENGE

SOLUTION

COMMENT

AUTHOR INFORMATION

Service de Dermatologie (Drs Parmentier, Prins, Masouyé, and Borradori) and Division de Chirurgie Orale (Dr Samson), Hôpitaux Universitaires de Genève, and Médecin Gastro-Entérologue (Dr Bron), Geneva, Switzerland. Dr Parmentier is now with Universitätsklinik für Dermatologie, Inselspital, Bern, Switzerland.